Behavior-Linked FoxP2 Regulation Enables Zebra Finch Vocal Learning
نویسندگان
چکیده
منابع مشابه
Behavior-linked FoxP2 regulation enables zebra finch vocal learning.
Mutations in the FOXP2 transcription factor cause an inherited speech and language disorder, but how FoxP2 contributes to learning of these vocal communication signals remains unclear. FoxP2 is enriched in corticostriatal circuits of both human and songbird brains. Experimental knockdown of this enrichment in song control neurons of the zebra finch basal ganglia impairs tutor song imitation, in...
متن کاملFoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
Human speech is one of the few examples of vocal learning among mammals yet ~half of avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared requirement for FoxP2 in both humans and zebra finches. We manipulated FoxP2 isoforms in Area X, a song-specific region of the avian striatopallidum analogous to human anterior striatum, during a critical period for so...
متن کاملFoxP2 expression in avian vocal learners and non-learners.
Most vertebrates communicate acoustically, but few, among them humans, dolphins and whales, bats, and three orders of birds, learn this trait. FOXP2 is the first gene linked to human speech and has been the target of positive selection during recent primate evolution. To test whether the expression pattern of FOXP2 is consistent with a role in learned vocal communication, we cloned zebra finch ...
متن کاملDevelopmental song learning in the zebra finch
Developmental learning (for example, speech acquisition in human infants) takes place early in life but its effects may last the entire lifetime of the individual. Developmental learning is difficult to study because the behavioral changes involved span many time scales: The challenge is to relate the developmental parameters to behavioral changes, which can occur within hours as well as across...
متن کاملPost-hatch neuron incorporation in the zebra finch caudomedial nidopallium (NCM) in relation to vocal learning
The songbird telencephalon continually receives new neurons. Peak levels of neuron addition in singing-related areas have been associated with maximal vocal learning. The caudomedial nidopallium (NCM), analogous to mammalian auditory association cortex, is a crucial brain region for acquiring tutor song memory. NCM contains a high number of inhibitory interneurons, including parvalbumin-express...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2015
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3715-14.2015